Shen H, Zhao J, Liu Y, Sun G (2018) Interactions between and shared molecular mechanisms of diabetic peripheral neuropathy and obstructive sleep apnea in type 2 diabetes patients. This improves the migration capability of bone marrow mesenchymal stem cells and repairs diabetic peripheral neuropathy, at least partly by activating the PI3K/Akt pathway through the SDF-1α/CXCR4 axis. Overexpression of neuritin in the bone marrow can locally ameliorate neuropathy in the bone marrow. Neuritin improves bone marrow mesenchymal stem cell migration via the SDF-1α/CXCR4-PI3K/Akt signaling pathway in vitro. Moreover, it ameliorated fat accumulation, adipocyte number, and vascular and nerve densities decreased glutamate content in serum and bone marrow restored gradient SDF-1α contents between bone marrow, blood, and sciatic nerve and promoted impaired diabetic bone marrow mesenchymal stem cell migration. Overexpression of neuritin in the bone marrow ameliorated hyperglycemia, prevented diabetic peripheral neuropathy, protected the ultrastructure of the sciatic nerve and intra-epidermal nerve fiber density, and promoted Schwann cell proliferation and remyelination in the sciatic nerve. Bone marrow-specific overexpression of neuritin in db/db mice was successfully established. Immunofluorescence, transmission electron microscopy, Oil Red O staining, and transwell migration assays were used.
![braveland blood and bones braveland blood and bones](https://images.gr-assets.com/books/1524487295s/36260146.jpg)
![braveland blood and bones braveland blood and bones](https://img.hdseries.cc/xxrz/1280x768/100/88/1e/881e94801a2bb0b99da9d5f6358208be/881e94801a2bb0b99da9d5f6358208be.jpg)
Antagonists were used to inhibit the stromal cell-derived factor (SDF)-1α/C-X-C chemokine receptor type 4 (CXCR4)-phosphoinositide 3-kinase (PI3K)/Akt signaling pathway in primary cultured bone marrow mesenchymal stem cells. We analyzed the impact of bone marrow neuritin overexpression on diabetic peripheral neuropathy and migration of bone marrow mesenchymal stem cells in db/db mice. The purpose of this study is to explore the effect and mechanism of neuritin overexpression in the bone marrow on peripheral neuropathy in type 2 diabetic (db/db) mice.